2018 旭硝子財団 助成研究発表会 要旨集

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Fig. 1. Burkholdine (2)Burkholdine Fmoc-LAPAsnNMe (Scheme 1) Scheme 1. Burkholdine (3) 8 [3][4]D-SerL-Asn NMe (4)β-HYY β-HYY4[5]β-HYYRalstonins A, B[6] 3. 4. [1] Tawfik KA, Jeffs P, Bray B, Dubay G, Falkinham JO, Mesbah M, Youssef D, Khalifa S, Schmidt EW (2010) Org. Lett., 12, 664-666. [2] Lin Z, Falkinham JOⅢ, Tawfik KA, Jeffs P, Bray B, Dubay G, Cox JE, Schmidt EW (2012) J. Nat. Prod., 75, 1518-1523. [3] Konno H, Otsuki Y, Matsuzaki K. Nosaka K (2013) Bioorg. Med. Chem. Lett., 23, 4244-4247. [4] Konno H, Abumi K, Sasaki Y, Yano S, Nosaka K (2015) Bioorg. Med. Chem. Lett., 25, 3199-3202. [5] Konno H, Sasaki Y, Sato R, Zhu X-M, Otsuki Y, Ikoma M (2016) Nat. Prod. Commun., 11, 213-218. [6] Murai Y, Mori S, Konno H, Hikichi Y, Kai K (2017) Org. Lett., 19, 4175-4178. 5. 992-8510 4-3-16 TEL&FAX: 0238-26-3131 E-mail: konno@yz.yamagata-u.ac.jp HP: http://www.bioorg.yz.yamagata-u.ac.jp HNNHHNOHNOHOOHONHNHONH2NHNHOOH2NOHOOONH2OONHBK-1097 analoguesOD/L-AsnD/L-TyrD/L-SerD/L-LAPor β-AlaD/L-AsnD/L-SerD/L-AsnGlyFmoc-Asn(Trt)-OHOAsnFmocTrt2-CTC resinDIPEA, DMFFmoc-SPPSH-LAP-DSer-DTyr-DAsn-Gly-Asn-Ser-Asn-OHtButBuTrtTrttBuTrtDIPC, HOBt, DIPEADMF, 12 hTFA/TIPS/H2O(95:5:5)rt, 2 hLAP-DSer-DTyr-DAsnAsn - Ser - Asn - GlyLAP-DSer-DTyr-DAsnAsn - Ser - Asn - GlytButBuTrtTrttBuTrtNNH2NNHHNNHHNNHHNNHNHOOOOOOOOOHOHOH2NOH2NOHOH2NONH2－57－