2018 旭硝子財団 助成研究発表会 要旨集

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22 1HPLC12 1LSD1Ki = 44 µM2Ki = 1.9 µM12Ki = 1.6 µM121HL-601 2) LSD1 H33) SNAIL1(1-9)LSD1H3K4M(1-20)20H3K4M(1-20)N SRTMQTARKSTGGKAPRKQL LSD1 SNAIL1 SNAIL1(1-9)LSD1 3 SNAIL1(1-9) 3. 4. 1) Umezawa N., Noro Y., Ukai K., Kato N., Higuchi T., ChemBioChem, 2011, 12(11), 1694-1698. 2) Amano Y., Umezawa N., Sato S., Watanabe H., Umehara T., Higuchi T., Bioorg. Med. Chem., 2017, 25(3), 1227-1234. 3) Amano Y., Kikuchi M., Sato S., Yokoyama S., Umehara T., Umezawa N., Higuchi T., Bioorg. Med. Chem., 2017, 25(9), 2617-2624. 5. 467-860331 : 052-836-3438 E-mail: umezawa@phar.nagoya-cu.ac.jp図３還元環境応答性LSD1阻害ペプチド11、直鎖ペプチド2SSOOOO12－37－